PBIT - JARID1 Histone Demethylases Inhibitor. CAS# 2514-30-9 Catalog No.:M60170-10S promoted cytokine independence and blocks

promoted cytokine independence and blocks differentiation in hematopoietic cells

Chemical Name: 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2

Ayrapetov MK

Formulation is 1% (v/v) solution of ethanol/solutol/water (10/40/50%)

PBIT - JARID1 Histone Demethylases Inhibitor. CAS# 2514-30-9 Catalog No.:M60170-10S promoted cytokine independence and blocksPBIT, CAS No. 2514 30 9, is a potent, specific, reversible and cell permeable inhibitor of Jumonji AT Rich Interactive Domain 1 (JARID1) histone demethylases. It inhibits JARID1B (also known as KDM5B or PLU1) with an IC of ~3 M in vitro. It also inhibits the activity of other related histone demethylases JARID1A, JARID1C, and JMJD2E with IC50 ~6, 4. 9, and 28 M respectively. PBIT does not affect the activity of unrelated UTX and JMJD3 H3K27me3